What is chronic endometritis?

Chronic endometritis is a persistent inflammation of the endometrium caused by an infection in the uterine cavity. It is mostly caused by bacteria that cannot be identified by traditional diagnostic like culture method .Making it impossible to treat with a specific antibiotic.​

Endometrial inflammation often has no visible symptoms but it causes chronic endometritis, which is one of the causes of infertility. It was found that 30% of women with infertility are caused by chronic endometritis. Moreover, 66% of women experiencing Recurrent Implantation Failure (RIF) or recurrent miscarriage were associated with chronic endometritis.

What is ALICE?

Analysis of Infectious Chronic Endometritis (ALICE) is a test that detects bacteria causing chronic endometritis. And recommend appropriate individual treatment.

How does ALICE work?

The doctor will collect a small sample of endometrial tissue. (Endometrial biopsy samples can be together used with ERA test). Next Generation Sequencing (NGS) technology is then used to analyze the genetic composition of bacteria that cause chronic endometritis. After analysis, the doctor will receive an ALICE report, which provides information on the bacteria that cause chronic endometritis. And make recommendations about appropriate antibiotics and probiotics, depending on the bacteria type detected. After antibiotic treatment, endometrial pathogenic bacteria were not be detected, the doctor will then transfer the embryo into the uterus ants with a suitable environment for embryo implantation. This will increase your chances of getting pregnant.

Why should I have an ALICE test?

ALICE provides accurate information that leads to successful treatment of chronic endometritis to increase the chance of getting pregnant.

If the ALICE test is positive, the report identifies the specific bacterial type causing the condition.

    • Optimal antibiotic and probiotic recommendations are based on the bacteria detected.​

Who should have an ALICE test?

1. ALICE is another option for women with infertility. Or those who suffer from recurrent implantation failure (RIF) or recurrent miscarriage to help increase the success of the pregnancy.

2. People who are treating infertility with assisted reproductive technology.