Preimplantation Genetic Testing For Monogenic Disorders
Preimplantation Genetic Testing (PGT-M) using NGS checks for single gene disorders when parents carry the condition and thus at risk of transmitting to their children. PGT-M allows us to select embryos free of a specific known disorders prior to implantation and pregnancy.
Possible candidates for PGD
Carriers of single gene disorders;
Couples who have a child/children affected by a single gene disorders;
Couples who have a family history of a single gene disorders.
Example of common single gene disorders in Asia
Hemophlia A (F8);
Hemophilia B (F9);
Autosomal Dominant Polycystic Kidney Disorders (ADPKD);
Autosomal Recessive Polycystic Kidney Disorders (ARPKD);
Duchenne muscular dystrophy;
Congenital Adrenal Hyperplasis;
Spinal muscular atrophy (SMA);
Fragile X Syndrome；
Deafness (GJB2 gene)
Example of rare single genes disorders
Osteogenesis Imperfecta I
We also offer PGD for other single gene disorders which require personalized development.
5 Steps to perform the PGD
Consultation, Provide us family history and the genetic reports, if already done. Answer within 3 days;
Pre-PGD, Genetic testing of wife, husband, and close relatives (prefer affected child) to identify the specific disorders mutation in the family, if not already done. Answer within 1 month;
IVF and Embryo Biopsy, Embryos are created and grown to the blastocyst stage;
PGD, Blood samples from the couple and from close relatives of known the disorders status are required. Answer within 2 months for common disorders and 4 months for less common disorders;
Normal Embryo Transfer.