Platelet Rich Plasma (PRP) is the platelet aggregation obtained by centrifugation to make it a concentration of 4-5 times more than platelets in the bloodstream in the body, in which PRP contains important substances called cytokines and growth factors, a protein group that will stimulate the stem cells to divide more number to restore and repair the damaged tissue to get new and healthy tissue. It is based on the same principles as the body’s natural self-healing when a wound occurs. Platelets form blood clots to stop the flow of blood and stimulate tissue regeneration to heal wounds. Therefore, a high concentration of platelets has higher amount of growth factors than the platelets in the blood stream. As a result, it can help restore and repair damaged tissues very well.
PRP is therefore used in a variety of medical areas, such as treating bone and joint injuries. Especially in athletes injured in training and competition, PRP helps to heal injuries without surgery. Or in the field of beauty enhancement, PRP is used to treat facial skin to stimulate tissue and collagen formation makes the skin radiant and smooth. In addition, PRP is also used to treat patients with cardiac muscle disease and use to treat for intra oral surgery as well .It can be seen that PRP has been used for many medical benefits. Because this is a safe method since the treated platelets are the platelets obtained from the patient himself. Therefore has a low risk of allergies and has no side effects.
PRP and infertility treatment
PRP is currently being used as a combination therapy with the treatment of infertility patients. The most common problems encountered by infertility are women as they get older will have fewer eggs because the quality of the eggs will deteriorate with increasing age. As well as may be caused by conditions that ovarian malfunctions or ovarian degeneration. This resulting in less number of eggs and egg quality. Therefore, PRP was injected into both ovaries to stimulate the ovaries to work better by growth factor a protein group will stimulate the stem cells of egg cells there will be development and division until getting more eggs. It also helps restore the degenerated egg cells to return to divide and develop into good quality eggs as well.
In addition to problems from the work of the ovaries that cause infertility. Another major cause is that the thin endometrial wall prevents the embryo from implanting. Even after IVF is performed until a good quality embryo is obtained ;however, if a patient has a thin endometrium thickness less than 7 mm, the embryo cannot be inserted. Therefore, PRP is injected into the uterus to stimulate endometrial tissue to divide and increasing in cell number helps to increase the thickness of the endometrium to be suitable for embryo implantation. In order to increase the chance of conceiving.
PRP for Ovarian Rejuvenation (PRP Treatment for Ovarian Rejuvenation)
Ovarian regeneration with PRP is a simple procedure. The treated patient can go home in 1-2 hours.The doctor will inject PRP into both ovaries at the best time when the very first day of menstruation before the development of the next egg cycle.
After PRP treatment, the doctor will monitor the results by doing ultrasound to measure the number of eggs and look at the size of the eggs as well as AMH, FSH, LH and estradiol level. If AMH increased while the level of FSH, LH and estradiol decreased, ovarian regeneration with PRP is successful. According to several studies that Ovarian regeneration with PRP can stimulate the aging eggs to grow and develop until the egg is in good quality. It was also found that when measuring AMH, the hormone that measures ovarian function, the ovaries treated with PRP had increased AMH activity, indicating that PRP was able to restore the ovaries to function well and helps restore youthfulness to the ovaries again.
Who is suitable for ovarian restoration with PRP?
• Women older than 35 years, because the older age the number of eggs will decrease and deteriorate with increasing age.
• Women with ovarian failure or ovarian dystrophy.
• Women who are younger than 40 years old but have ovarian malfunctions.
• Women with low AMH.
• Women who suffer from infertility with no known cause.
• Women who are unsuccessful in IVF because of poor quality embryos due to the low number of eggs and the deteriorating egg quality.
• Women under the age of 50, but began to go into premature menopause.
PRP for increasing the thickness of the endometrium (PRP Treatment for Uterine Rejuvenation)
Women with thin endometrium it can be caused by infection or due to chemical or radiation treatment, causing cells in the endometrium to divide and develop less. Although IVF technology is used to treat poor fertility, the embryo is of good quality. However, if it is detected that the thickness of the endometrium is less than 7 mm, the embryo transfer will not be considered. Because there is a high chance that the embryo will not be implanted causing the loss of the good quality embryo. Nowadays PRP is injected into the uterus, a growth factor in PRP stimulates a type of uterine stem cells called mesenchymal cells to divide the increasing in cell number makes the lining of the uterus thicker and suitable for embryo implantation where PRP is injected 48 hours before embryo implantation to prepare the endometrium to be thicker and suitable for embryo implantation for increasing the chance of conceiving.
Patient who cannot receive PRP treatment
1. People with low platelet count (Platelets less than 105,000 per microliter)
2. People with anemia (hemoglobin less than 10 grams per deciliter).